12th Ljudevit Jurak International Symposium on
Comparative Pathology
June 1-2, 2001

G. Petruševska, A. Stojanoviæ*, S. Karagozov**, B. Bogoeva, M. Tolovska, R. Jovanoviæ
Institute of Pathology, *Clinic for Hematology, 
**Surgical Clinic, Medical Faculty, University of ”Sv. Kiril and Metodij”, Skopje, R. Macedonia
The gastrointestinal tract including the oral cavity is the most common location of extra-nodal lymphomas. In the retrospective study we investigated the histomorphological, immunohistochemical and clinical features of 21 Macedonian cases with diagnosed malignant lymphomas. 
The series comprised of 15 males and 6 females. The mean age of the group was 44 years (4-78). The most frequently involved sites were hard palate (7 cases), gastric site (5 cases), small intestinal wall (2 cases), large intestinal wall (5 cases) and lingual root (2 cases). All cases of lymphomas were with a B cell nature. Out of them, 23,8 % were with low grade B cell lymphoma of MALT, 4,7% with mantle cell lymphoma, 47,6 % with diffuse large cell lymphoma, 23,8% with Burkitt type lymphoma. Cases with T cell lymphoma were not found. Most of the cases were positive for CD20 and CD79a. Monoclonality was confirmed by the restriction of the light chain, except in nine cases due to bad tissue preservation. The fact that  eight cases were in clinically advanced third and fourth stage, implied the conclusion that not only primary NHLs, but also secondary lesions could invade the gastrointestinal tract. Immunohistochemical staining was helpful in the differentiation between benign and malignant infiltration in low grade lymphomas, and in the distinguishing of diffuse large cell  lymphomas from undifferentiated epithelial neoplasms.
Key word: malignant lymphomas, gastrointestinal tract, immunohistochemical study....
Poster Presentation