12th Ljudevit Jurak International Symposium on
Comparative Pathology
June 1-2, 2001

S. Æuriæ-Juriæ, M. Šokèeviæ, I. Marièeviæ
Department of Cytology, University Hospital ”Sestre milosrdnice”, Zagreb, Croatia
The paper presents three cases of liver metastases of carcinoid tumor diagnosed by fine needle aspiration cytology. The patients were: one woman and two men aged 25, 44 and 79.. Two of them had clinically full-blown carcinoid syndrome and one had permanent respiratory disturbances and periodical flushing. Significantly high levels of 5-HIAA in 24h urine were found in all cases. The primary tumor was found  only in one case. Multiple focal lesions in the liver were demonstrated by CT-scan and/or ultrasonography. USG-guided fine needle aspiration was performed. In two cases smears were highly cellular, showing loose groups, occasional rosette-like formations and numerous single cells. Cells were small and fairly monomorphous with round to oval nuclei, finely granular chromatin and scanty to moderate amount of cytoplasm. Fine pink granules were conspicuous in the background and easily discernible in the cytoplasm. In one case the smears were bloody with smearing artefacts and scanty single cells. The cells were larger with abundant cytoplasm and rare pink granules. The immunocytochemical staining was positive for epithelial markers and chromogranin, negative for NSE, serotonin and calcitonin. In typical cases the carcinoid tumor has a distinct cytomorphology, but sometimes it may be indistinguishable from adenocarcinoma. Staining for chromogranin and the level of urine neuroendocrine metabolites can be helpful.

[1] Brian T. Collins et al., Acta Cytologica 1996, vol. 40, p. 695.

Poster Presentation