12th Ljudevit Jurak International Symposium on
Comparative Pathology
Zagreb
June 1-2, 2001
 

POSTER PRESENTATION
A TWENTY ONE YEAR COMPARATIVE STUDY OF MALE BREAST CANCER
H. Jurlina, M.Glasnoviæ, T. Lenièek, M. Elez, V.Gladiæ, I. Marton, M. Bel 
“Ljudevit Jurak” Clinical Department of Pathology, “Sestre Milosrdnice” University Hospital, Zagreb, Croatia
Aim: To carry out a retrospective study of male breast cancer cases, which were found in the cancer cases registry of the Clinical Hospital “Sestre Milosrdice” and to compare the findings to those found within other foreign clinical studies as well as to compare the results in intervals of Pre-war (1980-1990), War (1991-1995), and Post-war (1996-2000) periods.

Patients/Methods: Data was taken from 21 male patients (0.83%), out of a total of 2296 male and female patients whose breast cancer was diagnosed as a result of biopsies performed at the Clinical Centre of Pathology “Ljudvit Jurak” during the period of 1980-2000. The group of 21 was thus divided into three subgroups labelled as Pre-war (1980-1990), War (1991-1995) and Post-war (1996-2000) periods.

Result: All of the 21 reported cases of male breast cancer were of the infiltrating ductale carcinoma type, which corresponds with the findings of other foreign clinical studies, which state that most or all of male breast cancers were of the infiltrating ductale type. The median age of 62.4 found within the 21 cases in the 21 year period is on the lower end of an average age scale which ranges from 63 to 67.0 years. Also, the average percentage of breast cancer that belonged to the male population of breast cancer patients was 0.83%, which is less than the 1.0% reported by other clinical studies. Once the 21 patients were divided into their respected subgroups the average percentage of male breast cancer cases belonging to the subgroups were compared to each other and an increase from 0.8% during the Pre-war period (1980-1990) to 1.5% during the War period (1991-1995) was seen, with a slight dip to 1.4% during the Post-war period (1996-2000). Also the mean age of the Pre-war and War periods were 63.6 and 63.5 but the Post-war period of 1995-2000 showed a drop of 4.7 to 58.8 years. Estrogen and progesterone receptor readings were taken from 8.3% of patients during the Pre-war period (1980-1990), 60.0% of patients during the War period (1991-1995) and 60.0% of patients during the post-war period (1996-2000). The Pre-war period (1980-1990) showed that all (100.0%) of the receptors were ER+PgR+. The War time period (1991-1995) showed that 33.3% of receptors were ER+PgR+, 33.3% were ER+PgR- and 33.3% were ER-PgR-. While in the Post-war period (1996-2000) 66.7% of receptors were ER+PgR+ and 33.3% of receptors were ER+PgR-. The average number of receptors in each patient within the three periods were 270.2 estrogen receptors and 26.7 progesterone receptors in the Pre-war period, 72.8 estrogen receptors and 163.7 progesterone receptors in the War period and 38.9 estrogen receptors and 480.4 progesterone receptors in the Post-war period.

Conclusion: The type of breast cancer (invasive ductal carcinoma) within the 21 patients completely corresponded with the type of breast cancer found in the greater majority of males suffering from breast cancer reported in other (foreign) clinical studies. Although the 21 male breast cancer patients had a lower percentage of total breast cancer cases (0.83%) than those of other clinical studies (1.0%) as well as a lower than average mean age (62.4), the drop of the mean age in the Post-war period (1996-2000) of 4.7 to 58.8 years and the increase in the average percentage of male breast cancer cases in the War (1.5%) and Post-war (1.4%) period shows a younger generation of male breast cancer patients with a greater percentage of occurrence. 

LITERATURE:
1.Lamma F. et al. Minerva Chir 1997 Jun;52(6):847-9 
2.Donegan WL. et al. Cancer 1998 Aug 1;83(3):498-509 
3.Goss PE. et al.Cancer 1999 Feb 1;85(3):629-39 
4.de Perrot M et al. Eur J Surg 2000 Dec;166(12):929-31

Poster Presentation