12th Ljudevit Jurak International Symposium on
Comparative Pathology
Zagreb
June 1-2, 2001
 

POSTER PRESENTATION
THE FREQUENCY OF METASTATIC ADENOCARCINOMAS COMPARED TO THE INCIDENCE OF OTHER METASTATIC CARCINOMAS OF THE CNS
N. Ugarkoviæ, J. Talan - Hraniloviæ, M. Belicza,
”Ljudevit Jurak” University Department of Pathology,
”Sestre milosrdnice” University Hospital, Zagreb, Croatia
The Aim of this study is: 
1. To present the incidence of  metastatic adenocarcinomas of the central nervous system (CNS).
2. To point out problems of primary tumors.
3. compare the incidence of metastatic adenocarcinomas of the CNS with the incidence of other metastatic carcinomas of the CNS.
Methods: The biopsies of metastatic carcinomas from 1996 - 2001 were analized using these parameters: sex, age, localization and distribution.Origin of the CNS metastases was determined within the group of metastatic adenocarcinomas..
Results are presented in Table 1. and 2.
 
Table 1. Metastatic carcinomas of the CNS in the period from 1996 - 2001
LOCALIZATION
NUMBER
SEX
MALE     FEMALE
AVERAGE
(Age)
Brain
80
53
27
57,95
Cerebellum
27
17
10
61,76
Pituitary gland
1
0
1
58,00
Spinal cord
1
0
1
66,00
Brain and cerebellum
2
2
0
61,00
Total
111
62
39
60,94

 
Table 2. Metastatic adenocarcinomas of the CNS in the period from 1996 - 2001
LOCALIZATION
NUMBER
SEX
MALE  EMALE
AVERAGE
(Age)
ORIGIN
Brain
10
3
7
58,80
3 of GIT
4 of lungs
3 unknown
Cerebellum
3
2
1
59,00
1 of GIT
1 of bronchi
1 unknown
Brain and cerebellum
1
1
0
63,00
1 of bronchi
Total
14
6
8
60,23
GIT - gastrointestinal tract

In 111 cases of metastatic carcinomas of the CNS only 14 there were  metastatic adenocarcinomas. In 14 cases of metastatic adenocarcinomas of the CNS 10 were in the brain, 3 in the cerebellum, 1 was simultaneously in the brain and cerebellum. Only 4 of these 14 metastatic adenocarcinomas originated from the  gastrointestinal tract (28,57%), 4 from the lungs (28,57%), 2 from the bronchi (14,28%) and for 4 the origin was unknown (28,57%). 
The male  female ratio for cerebral metastases was 1,59 : 1.
Discussion: Frequency of metastatic carcinomas in CNS increases  with age. According to the literature the male female ratio for cerebral  metastases is 1,36 : 1. Intracranial metastases are 80% in the brain and 15 % in the cerebellum. The most common origin of intracranial metastases are bronchial carcinomas, breast carcinomas, kidney carcinomas and carcinomas of  the gastrointestinal tract.

References:

  1. Nelson JS. et al. Metastatic tumours of the CNS in Kleihues P. 
  2. Cavenee WK. Pathology & Genetics tumours of the nervous system, IARC Press, Lyon, 2000: 250-53.
  3. Posner JB. Neurologic Complications of Cancer, Davis FA. Philadelphia, 1995.
  4. Percy AK. Elveback LR. Okazak H. et al. Neoplasmas of the central nervous system, Epidemiologic considerations, Neurology, 1972; 22: 40-48.
  5. Zülch KJ. Brain tumors, Springer  Verlag, Berlin Heildeberg, New York, Tokyo, 1986: 492.
Poster Presentation