12th Ljudevit Jurak International Symposium on
Comparative Pathology
Zagreb
June 1-2, 2001
 

POSTER PRESENTATION
A CASE REPORT: PULMONARY LEIOMYSARCOMA IN  DOG PRESENTING AS A PSEUDOANEURYSM LEFT VEIN JUGULARIS
M. Kostov, V. Katiæ*, D. Dimov*, S. Stošiæ, D. Simiæ
Department of Pathology, Military Hospital Niš, Niš, Yugoslavia
*Institute of Pathology, in Niš University, Niš, Yugoslavia
AIM: Pulmonary sarcoma is a rare tumor of the lung found in dogs. The clinical and pathologic features of primary pulmonary leiomyosarcoma were analyzed. 
CASE REPORT: The authors autopsy report showed a case of pulmonary leiomyosarcoma in a 9-year-old dog presented as a pseudoaneurysm of the left vein jugilaris. The presented signs and symptoms were swelling of the neck and legs, dyspnea, malaise and weight loss. An operation of the aneurysm left vein jugilaris was performed. He died 15 days after operation. The tumor was not found during the life of the dog but, accidentally, found during the autopsy. 
MATERIALS AND METHODS: A number of tissue specimens taken from organs during autopsy were routinelly fixed and processed. Paraffine sections were stained by the standard H@E metod, and the following histochemistry metods: PAS, PAS-D, Von Gieson, PTAH (for muscle) and Masson trichrom. Immunohistochemical examination with antibodies against aktin, vimentin and S-100 protein were used, too. 
RESULTS: Large tumour masses in both lungs were found at the time of the autopsy, as well as the metastatic of the heart and left kidney. Immunohistochemical stains showed a strong positive reaction for S-100 protein and vimentin, but a weakly positive for aktin. Histochemical studies showed that paraffin sections stained positively with PAS, PAS-D, Masson trichrome and Von Gieson metods. 
CONCLUSION: On the basis of histochemical and immunohistochemical examination we concluded that the tumor was a primary pulmonary leiomyosarcoma. A pathological differential diagnosis of leiomyosarcoma of the lung from anaplastic lung cancer (included sarcomatoid carcinoma) and other sarcomas is difficult. Immnunohistochemistry microscopy can be helpful in distinquishing primary pulmonary sarcoma from other tumors in the differential diagnosis. 
Poster Presentation