12th Ljudevit Jurak
International Symposium on
June 1-2, 2001
|A CASE REPORT: PULMONARY LEIOMYSARCOMA IN
DOG PRESENTING AS A PSEUDOANEURYSM LEFT VEIN JUGULARIS
V. Katiæ*, D. Dimov*, S. Stošiæ, D. Simiæ
Department of Pathology, Military Hospital
Niš, Niš, Yugoslavia
*Institute of Pathology, in Niš University,
|AIM: Pulmonary sarcoma is a rare tumor of the lung found in dogs. The
clinical and pathologic features of primary pulmonary leiomyosarcoma were
CASE REPORT: The authors autopsy report showed a case of pulmonary
leiomyosarcoma in a 9-year-old dog presented as a pseudoaneurysm of the
left vein jugilaris. The presented signs and symptoms were swelling of
the neck and legs, dyspnea, malaise and weight loss. An operation of the
aneurysm left vein jugilaris was performed. He died 15 days after operation.
The tumor was not found during the life of the dog but, accidentally, found
during the autopsy.
MATERIALS AND METHODS: A number of tissue specimens taken from organs
during autopsy were routinelly fixed and processed. Paraffine sections
were stained by the standard H@E metod, and the following histochemistry
metods: PAS, PAS-D, Von Gieson, PTAH (for muscle) and Masson trichrom.
Immunohistochemical examination with antibodies against aktin, vimentin
and S-100 protein were used, too.
RESULTS: Large tumour masses in both lungs were found at the time of
the autopsy, as well as the metastatic of the heart and left kidney. Immunohistochemical
stains showed a strong positive reaction for S-100 protein and vimentin,
but a weakly positive for aktin. Histochemical studies showed that paraffin
sections stained positively with PAS, PAS-D, Masson trichrome and Von Gieson
CONCLUSION: On the basis of histochemical and immunohistochemical examination
we concluded that the tumor was a primary pulmonary leiomyosarcoma. A pathological
differential diagnosis of leiomyosarcoma of the lung from anaplastic lung
cancer (included sarcomatoid carcinoma) and other sarcomas is difficult.
Immnunohistochemistry microscopy can be helpful in distinquishing primary
pulmonary sarcoma from other tumors in the differential diagnosis.