12th Ljudevit Jurak
International Symposium on
June 1-2, 2001
|THE ASSOCIATION BETWEEN LONG-TERM COMPLICATIONS
OF DIABETES, AND ITS CONTROL
P. Stradina Hospital, Department of Endocrinology, Riga, Latvia
|We estimated the prevalence of long-term complications in diabetes
(both types) and associated them with the control of diabetes and the potentially
modifiable risk factors for diabetes including obesity, body fat distribution
and life-style factors such as physical activity.
We evaluated the interrelationships between rates of diabetes, long-term
complications, glycemic control and also the differences between the complications
in different types of diabetes.
The analysis included 100 persons aged 25 to 76 years with diabetes
mellitus (41 with type I, 59 with type II) at the P. Stradins Hospital,
Department of Endocrinology, Riga, Latvia. We used complete questionnaires,
blood analysis data (creatinine, profile of lipoproteins, proteins); urine
samples; BMI; and detection of microalbuminuria. Glycemia was evaluated
by using glycosylated hemoglobin concentration.
We concluded that diabetes control is of critical importance
for prevention of serious complications including neuropathy, nephropathy,
and retinopathy. Some of the patients with diabetic complications had poor
glycemic control, with glycosylated hemoglobin concentrations above 8%,
which placed them at high risk of long-term complications.
Type I and type II diabetes differ in their etiology and risk factors
for cardiovascular disease. Type II diabetes is associated with insulin
resistance and often obesity, leading to hyperinsulinemia, beta-cell dysfunction,
hyperglycemia, and eventually insulin deficiency.
Cardiovascular disease is linked mainly to insulin resistance in diabetes
type II; while cardiovascular disease in type I diabetes is closely linked
to renal pathology.
The main long-term complication in diabetes type I is nephropathy,
while in diabetes type II the leading long-term complication is coronary