12th Ljudevit Jurak International Symposium on
Comparative Pathology
Zagreb
June 1-2, 2001
 

POSTER PRESENTATION
SOME ASPECTS OF MODERN ANTIHELICOBACTER THERAPY (CLINICAL AND MORPHOLOGICAL STUDY)
N.V. Bogomolova, N.A. Bigeldina, N.G. Dudaeva
Saratov State Medical University, Saratov, Russia
The aim of the study was to estimate the effectiveness of various approaches in combined antihelicobacter therapy based on clinical, endoscopic and morphological criteria.
The study was based on a group of 102 patients diagnosed as having stomach and duodenal ulcer whose  age ranged from 17 to 76 (81.4% male, 18.6% female). All the patients were divided into 3 groups according to the treatment approaches used. Chronic gastritis was diagnosed according to the Modified Sydney System criteria (1996). In the first group, a correlation analysis discovered stomach and duodenal ulcer healing time to be directly dependant on the patient ages, ulcer size and Helicobacter pylori (HP) seeding rate expressed. In the second group, ulcer healing time dependence is statistically reliable only in relation to ulcer damage size. In the third group, ulcer healing time was absolutely independent of the studied parameters. In all three groups, the treatment approach (P = 0.012) and a combination of stomach and duodenal pathology (perfunctory gastritis and gastroduodenitis) (P = 0.036) have a reliable influence on healing time. Recurrences in the third group were only 6.9%, whereas in the 1st and 2nd group  they were 40.6% and 34.1%, correspondingly. Method of treatment, age, ulcer localisation and HP eradication degree have a reliable influence over recurrence development in all three groups.
Conclusions:
1. Healing time depends on the patients age, ulcer size, HP seeding rate, stomach and duodenal mucous membrane developments as well as on the treatment approach used.
2. Disease recurrence is greatly influenced by the following three factors: age, ulcer damage localisation and the reinfection level.
Poster Presentation