12th Ljudevit Jurak
International Symposium on
June 1-2, 2001
|MORPHOLOGICAL CHARACTERISTICS AND SURVIVAL AFTER
SURGICAL THERAPY OF COLORECTAL CANCER IN REGION OF NAŠICE
D. Lenz, V. Ilakovac
General Hospital, Našice, Croatia
|Colorectal carcinoma has a wide distribution in Croatia, with the highest
incidence rate in Istria, Slavonia and region of Dubrovnik. (1) Colorectal
cancer is the second most common fatal malignancy in both sexes combined,
after lung cancer. Colorectal cancer is largely an environmental disease,
but genetic susceptibility has an important role. Two highly penetrating
autosomal dominant predisposition syndromes: hereditary non-polyposis colorectal
cancer and familial adenomatous polyposis together account for 2-10% of
all cases of colorectal cancer.
The overall five-year survival rate is around 40%, but survival can
be as high as 70% after curative surgery. The morbidity associated with
the disease and its treatment is considerable. Almost all patients require
surgical resection. Unfortunately, palliation is the only realistic hope
for the substantial proportion of patients who already have disseminated
disease. (2,3) One hundred and four cases of colorectal carcinoma were
analyzed after surgical and oncological treatment in interval years (1986.-1999.)
All patients were mostly of the rural regions. The data about patients
includes sex, age, date of operation and date of death. The data regarding
colorectal tumors includes size, localizations, involvement of the circumference
wall bowel, histological type of the tumors, number of metastatic involvement
of lymphatic nodules, histological differentiations tumor tissues, pathological
staging, and prevalence of adenomas. Survival probabilities were estimated
by the univariante Kaplan-Meier method.
Multivariate analyses were performed by the Cox regression model.
This paper describes morphological characteristics of colorectal tumors
and survival after surgical and oncological treatment.
Turiæ M, Kolariæ K, Eljuga D. Klinièka onkologija. 1.
izd. Zagreb: Nakladni zavod Globus, 1996:557-627.
Boyle P, Zardze DG., Smans M. Descriptive epydemiology of colorectal cancer.
Int J Canc 1985;36(1):9-18.
Adami HO. Aspects of descriptive epidemiology and survival in colorectal
cancer. Scand J Gastroenterol 1988;149:6-20.