12th Ljudevit Jurak International Symposium on
Comparative Pathology
June 1-2, 2001

M. Kos, S.Jukiæ, D.Babiæ, J. Iliæ-Forko, Lj. Hlupiæ
Department of Gynaecological and Perinatal Pathology, Medical School University of Zagreb, Croatia
Aim: To determine types and frequencies of congenital gastrointestinal (G-I) tract malformations on post mortem in the period from 1996. to 2000.
Materials and methods: Autopsy protocols of aborted fetuses, stillborn infants and infants that died within 7 days after delivery were retrieved from the archive and analysed. Cases of cleft lip and/or palate, biliary tract, pancreatic and diaphragmal malformations were not included in the study.
Results: During five years 1251 autopsies were peformed with 127 of them showing some sort of malformation. G-I tract malformation was diagnosed in 37 cases (2,9% and 21,5%, respectively). Isolated G-I malformation was diagnosed in 32,4%, different but simultaneous G-I malformations in 5,4% and a combination of G-I malformations with malformation(s) of other organ system(s) in 62,2%. The most frequent isolated malformation was omphalocoele (41,6% of isolated malformations). When combined with other organ system malformations, omphalocoele was as frequent as rectal and anal atresia (34,8% of combined malformations each), while the frequency of oesophageal atresia (with tracheoesophageal fistula in all cases) was somewhat lower and gastroschisis even more so (26,1% and 4,3% of combined malformations, respectively). Other organ systems affected by malformation besides the one of G-I tract were: urogenital in 65,2%; cardiovascular in 52,2%; skeletal in 26,1%, CNS in 17,4% and other in 30,4%.
Discussion: Some results of this study are similar to those already published yet from differ somewhat the figures in relevant literature. The reason could perhaps be attributed to methodology, i.e. exclusion of the cleft lip and palate and diaphragmal malformations that are raltively frequent and could influence the total number as well as the frequency of G-I malformations.