12th Ljudevit Jurak
International Symposium on
June 1-2, 2001
|CONGENITAL GASTROINTESTINAL TRACT MALFORMATIONS
IN A 5-YEARS POST MORTEM SERIES
|M. Kos, S.Jukiæ,
D.Babiæ, J. Iliæ-Forko, Lj. Hlupiæ
Department of Gynaecological and Perinatal Pathology, Medical School
University of Zagreb, Croatia
|Aim: To determine types and frequencies of congenital gastrointestinal
(G-I) tract malformations on post mortem in the period from 1996. to 2000.
Materials and methods: Autopsy protocols of aborted fetuses,
stillborn infants and infants that died within 7 days after delivery were
retrieved from the archive and analysed. Cases of cleft lip and/or palate,
biliary tract, pancreatic and diaphragmal malformations were not included
in the study.
Results: During five years 1251 autopsies were peformed with 127 of
them showing some sort of malformation. G-I tract malformation was diagnosed
in 37 cases (2,9% and 21,5%, respectively). Isolated G-I malformation was
diagnosed in 32,4%, different but simultaneous G-I malformations in 5,4%
and a combination of G-I malformations with malformation(s) of other organ
system(s) in 62,2%. The most frequent isolated malformation was omphalocoele
(41,6% of isolated malformations). When combined with other organ system
malformations, omphalocoele was as frequent as rectal and anal atresia
(34,8% of combined malformations each), while the frequency of oesophageal
atresia (with tracheoesophageal fistula in all cases) was somewhat lower
and gastroschisis even more so (26,1% and 4,3% of combined malformations,
respectively). Other organ systems affected by malformation besides the
one of G-I tract were: urogenital in 65,2%; cardiovascular in 52,2%; skeletal
in 26,1%, CNS in 17,4% and other in 30,4%.
Discussion: Some results of this study are similar to those
already published yet from differ somewhat the figures in relevant literature.
The reason could perhaps be attributed to methodology, i.e. exclusion of
the cleft lip and palate and diaphragmal malformations that are raltively
frequent and could influence the total number as well as the frequency
of G-I malformations.